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KMID : 0356720090250020107
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Journal of the Korean Society of Coloproctology
2009 Volume.25 No. 2 p.107 ~ p.112
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Clinical Significance of p53 and Ki-67 Expression in Colorectal Cancer
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Huh Jung-Wook
Kim Hyeong-Rok
Cho Sang-Hyuk
Kim Young-Jin
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Abstract
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Purpose: This study aimed to evaluate the clinical significance of p53 and Ki-67 expressions in patients with colorectal cancer.
Methods: Immunohistochemical expressions of p53 and Ki-67 in 205 patients with colorectal cancer were examined. Results were correlated with clinical and pathological parameters.
Results: Overexpression of p53 was significantly associated with a proximal location of the tumor (P=0.031) and with lymph node involvement (P=0.030); however, Ki-67 expression was not correlated with any of the clinicopathological variables.Positive p53 staining was significantly associated with a higher level of Ki-67 (P=0.009).
Conclusions: Overexpression of p53 was strongly correlated with lymph node metastasis in colorectal cancer; thus, p53 may be used as a possible prognostic marker in patients with colorectal cancer.
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KEYWORD
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p53, Ki-67, Colorectal cancer
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